Vitiligo Treatments

Vitiligo Treatments - The surgical treatment of vitiligo:

• When topical steroids or not repigment PUV therapy, surgical treatment May be made. Therapies surgical lot of time and can be seen in inactive, not only progressive disease. They are located and adapted for segmental vitiligo. Areas such as fingers, ankles, forehead and hairlines tend to show poor results.
• minigrafting autologous. Multiple, small punch biopsies are taken from an area donor and recipient vitiligo treatments, where sites are biopsy
• separated by 4 to 5 mm vitiliginous skin. The donor is put into the receiver defects and transplants are sealed. Centrifuges pigmentation extends from the site receiver. PUV concomitant therapy can help to disseminate the pigments. This procedure can produce excellent results in the segmental vitiligo. An appearance pavers or scarring can occur rather than treatment.
• skin graft concerning the formation of blisters on the donor and recipient sites using a suction device and remove the roof of blisters. The roof of the blisters from donor sites are located in areas sites denudadas receivers and bandages are applied in both donor and recipient sites.
• Transplantation in vitro culture of melanocytes in vitiliginous receptor sites denudadas has also been successful in producing cosmetically acceptable repigmentación vitiligo.

Despigmentación of vitiligo:
In patients with vitiligo, depigmentation other islands of normal skin May be more acceptable cosmetically. To achieve this objective, monobenzyl ether of hydroquinone in a concentration of 20% is applied twice a day on skin pigmentation. It May take months to establish depigmentation, which is usually permanent.

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Labels: Vitiligo Surgical Treatments, Vitiligo Treatments

vitiligo Treatment

• There are several options for the vitiligo treatments. The most common form of systemic treatment or a topical vitiligo treatments PUV (psoralen + ultraviolet A), which involves the use of compounds psoralen followed by exposure to UV radiation in the range of 320 to 400nm (or ultraviolet rays). Corticosteroids are also used in the management of vitiligo. Multiple vitiligo treatments surgical procedures are also available for some patients. In vitiligo universal depigmentation other islands of normal skin May be the only option acceptable cosmetically.
• repigmentación are generally occurs around hair follicles, which is produced by stimulation of melanocytes follicular and migration. Propagation of the margin of the pigmentation of the macula may also occur.
• Whatever the mode of treatment, patient education and reassurance is of paramount importance. Explanation of the benign nature of the disease and appropriate counselling and psychological support is necessary in all patients.
• topical steroids are effective in managing the disease limited to small. The face and neck injuries respond better than other parts or body. Hydrocortisone is the current agent of choice. More powerful steroid also can be used intermittently.
• PUV therapy: The use of substances known collectively photoactive psoralenos, in conjunction with exposure to long-wave ultraviolet (UVA), whether by artificial sources or by exposure to the sun remains the mainstay of the management of vitiligo . The exact mechanisms of action of PUV in vitiligo remain speculative, but its main activities involve the proliferation and migration of melanocytes and greater enzyme activity of the melanin biosynthesis.
• The therapeutic agents are used mainly methoxycinnamate ¬ 8 (8-MOP) and trimethyl psoralen (TMP). Psoralène ideally be used under the supervision using artificial UV radiation source. From the computer of UV is not universally available, the use of solar UV radiation exposure to sunlight is the best alternative. This form of treatment is called PUVASOL therapy.
• PUV news / PUVASOL the paint with a low solution of 8-MOP and expose the area to UVA, after which the area is completely washed with soap and water. Patients with a low rate (less than 10% of body surface area) are better suited to this form of therapy. The solutions must be diluted commercially available (for example, 1:50 or more alcohol) in order to avoid serious phototoxic reaction. The increase in concentration perhaps later, depending on the answer. Initially, the injury must be exposed to the sun for a few minutes, the exposure time that the gradual increase.
• oral PUV / PUVASOL is used in patients with vitiligo extended. Two hours after ingestion of 0.6mg/kg 8-MOP, patients are exposed to artificial sources of PUV 2 to 3 times per week. TMP is preferable that PUVASOL therapy. The best time to sun exposure is 10 hours. 2 hours. Sun exposure is primarily limited to 10 minutes. After a gradual increase in exposure time is allowed on the basis of the response (redness and tenderness). Up to 80% of patients will induce pigmentation, less than 20% of patients repigmentación total to 30% to 40% of patients can expect to have only a partial response to treatment. Vitiligo on the lips, palms and soles, advice finger bone, and periorificial areas react very badly. Psoralène repigmentación induced can remain stable for many years. New However, injuries May at the same time develop therapy PUV. They can repigment the further processing.
• possible side effects of treatment PUV phototoxicity, nausea, stomach discomfort, itching, tiredness, cataract, pigmented lesions and possibly carcinogenicity. PUV therapy is best avoided in children younger than 12 years. It is against-indicated in pregnancy and lactation, photosensitivity disorders or cataracts.
• Patients should be warned to take ophthalmic annual attrition and the absorption of UV glasses for 24 hours after treatment.

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Labels: Vitiligo Treatments